Aluminum is an anode so it is recommended to prevent contact to stainless steel or other cathodes to prevent corrosion of the anode.
Ex. use of top hat washer to prevent contact of stainless steel bolt and galvanized steel section.
If the anode is a much larger component compared to the...
If the hole sizes or edge distances are beyond the limits in the code, do an analysis (finite element analysis, etc) to determine the effects on beam capacity more accurately. It is similar to castellated beams (where the holes are in the web instead of the flange) and there are plenty of...
