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As you said the gasket is suitable both for ANSI B16.5 and API 6B, and for the classes you have mentioned. The difference is between the dimensions of flanges ( for a valve 3000# you must use API 6A flange dimensions and not B16.5, or you must calculate the flange with a code-as ASME VIII )...

In my experience is more frequent solid wedge for low pressure also for big size velves, you can find also flex wedge, instead parallel or double disc are unusual.. For this kind of valves is better to foresee a relief device for overpressure in the body neck, especially for vapour/steam...

You can design a "not standard" buttwelding end following the figures of B16.25(for small sizes fig.2) using the outside diameter and the thickness of the pipe (for example B36.10 dimensions). In this way you can calculate the inside diameter of weld preparation. Usually, for cast products...

It's a frequent problem in valve design... If you have the mechanical properties of the material at the different temperatures(for example from ASME II) you can easily define a rating according to ASME B16.34 Appendix (But you cannot mark the valve as ASME B16.34!) Otherwise I think you need to...