Not sure if you're still figuring this out, but I've found that using Creo 2 M100 seems to launch and run ok on Windows 10, despite not being supported. However, interestingly, if you launch it using compatibility mode (Windows 7) it does not launch.
Using Wildfire 4 with Windchill 10.
Working on large assemblies or large assembly drawings, when I press Save the following occurs (every time):
1) Conflict screen popup that says it skipped regeneration of read-only components. No Actions available so I press OK.
2) The dialog that confirms...
