The vane pass pulses should be quite irrelevant, care should however be taking to protect piping/equipment from sudden changes in valve positions, and gas pockets in fluid causing hammering. If all piping is properly bolted and supported it will withstand a lot more abuse than vane pass pulses...
The location of the hole in the tubing won't matter, as you will POOH until you either visually find the hole, or you get to the ESP. I think this activity will require a service rig in any circumstance as you are limited in troubleshooting an ESP.
You should troubleshoot as you would any...
