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Screws with nuts. That's what we do when bolting together aluminum frames for fabric covered buildings. I've never seen it result in a problem.

Just make sure you pay some attention to proper workstation ergonomics when setting up your desk and workstation. Sitting behind a desk all day can do long-term damage if you have bad posture. A good chair and a keyboard tray are good first steps.

A little hard to understand the questions. Maybe you'd be interested in Mining Visualization Systems (MVS)? Or other tools?