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  1. Luisa89

    Active Pharmaceutical Ingredients (APIs) Manufacturing Process (Synthesis and Fermentation)

    Dear all, I don't know if this is the right module of the Forum for asking you what I need. I am trying to search something useful for studying APIs manufacturing production (synthesis process and fermentation). Please, could I kindly ask you to help me in this reasearch or advice any...
  2. Luisa89

    Reynolds and Velocity_Clean Utilities in Pharmaceutical Industries

    Dear all, thank you so much for the useful answers and for all you help. Now it is very clear. Regards, Luisa
  3. Luisa89

    Reynolds and Velocity_Clean Utilities in Pharmaceutical Industries

    Dear all, sorry for bothering you again. Please, could you help me about the value of clean utilities velocity in Pharmaceutical Industries, according to the normatives. Sorry, I don't know how specifical normative reports this value. It is necessary to ensure turbolent regime in order to avoid...
  4. Luisa89

    PED for piping in a pharmaceutical plant

    Dear all, please I ask your help for a valuation of PED for piping. Could you please write me when a piping is classified as PED? And could you give me the definition of "full vacuum" for a piping? Sorry for the commonplace questions and thanks for all your support. Luisa
  5. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    At the end, I have found that 1/N <= 0,7^2 * Dp^2 *pi^2 / (4*Ao). Hope this is the right way to solve. Plaese, give me your feedback, if you want. Thank for all, Luisa
  6. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Dear Pierre, if I consider the following formulas: - DeltaPp=pressure drop in pipe caused by friction=alfa*rho*Vp^2/2, see formula (1), and I explicit Vp as a function of the volumetric flow rate Qp, what I obtain is = alfa*rho*(Qp/Ap)^2/2, where Qp=know value (25Nm3/h to convert in Nm3/s)...
  7. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Dear Pierre, thank you for the document you have sent to me. It is very insteresting. The only formula I have to use is (5), but I have n°2 unknown values (the diameter of the single hole, D0, and the number of the holes, N). It is necessary to fix at least one of the unknown values, right...
  8. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Dear all, in detail, - Our perforated-pipe distributor, or sparger, must have pharmaceutical charateristics. So it must be in AISI 316L stainless steel, not in carbon steel. - The depth must be defined. Regarding this argument, please what are the parameters to be considered for having the...
  9. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Please, try now and refer to N2 lines. Luisahttps://files.engineering.com/getfile.aspx?folder=5e4aaac2-c6ab-4325-8730-f430ffba2f8a&file=1K3021010-SM-0001_01_Preparation_Ampoules_Line_2_Fase_di_riscaldamento_page-0001.jpg
  10. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Dear all, I ask you pardon for my inadequate information. This is my fist approch to a pure engineering design. For this reason, I ask you a little piece of patience, if I am not very clear during my explanation. Please, I try to write you all the details I have. You can find a P&ID detail in...
  11. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Dear pierreick, thanks for the brochure. Anyway, I would need a procedure or a formula for dimensioning this kind of sparger. We have just seen on the vendor website. Something useful is written, but at the end it is necessary to decide the sparger configuration according to Mott sparger types...
  12. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Dear Latexman, clean service. Nitrogen is used to deoxygenate the aqueous solution during its preparation. I have found in Internet this procedure https://www.cheresources.com/invision/blog/4/entry-353-perforated-pipe-distributor-sizing-calculations/ , but dimensionally I think something is...
  13. Luisa89

    Perforated Pipe Distributor Design for diffusion of gas in a aqueous solution

    Hi everyone. please, I need some help for a project I am working on. My collegues and I are designing a pharmaceutical vessel for the preparation of injectable solutions. Now we need to design a gas sparger (in particular, Nitrogen sparger). The only data we have are the gas flow rate (25...

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