Considering the plane of angular acceleration, the I-beam seems better. OTOH, the "width" of the rod is constrained by the bore spacing and the need to share space with the crank cheeks and other rod & main bearings. Thus perhaps making the plane of the rod beam longitudinal (i.e. "H-beam" design) improves the buckling strength in the inherently weaker (because the depth is constrained to be narrower) plane. Though I haven't done the bending/buckling stress analysis, my gut says a well engineered H-beam rod is stronger for this reason (considering that the flanges can be made as wide necessary for the required strength in the lateral plane).
BTW, I have a real world experience of rods being "squished" (shortened) very slightly, under the stress of knock, without any visible bending. I did a compression stress analysis that indicated this was indeed possible with cylinder pressures exceeding 2000 psi and the connecting rods in question. The plastic strain was approximately 0.020" in the worst rod, IIRC.