RJB32482,
As a general comment, I find your description of the relief valve inlet and outlet piping as a "header" to be a little confusing. A header is typically a pipe to which several other pipes might be connected but I don't get that impression from your example. From your example, it sounds like you may have a positive displacement pump with a relief valve on the pump discharge with the relief valve discharging back to the pump suction, is that your system?
Latexman is correct about having to account for the superimposed and builtup backpressures but if the system is a positive displacement pump with a relief valve discharging to the pump suction then superimposed backpressure can be a significant concern.
When talking about systems like the one I've described for a PD pump, it is more typical to think of the relief valve setting in terms of "psi" or "psid" where "d" indicates differential rather than psig (gauge). To be on the safe side, be sure and check what the relief valve cold differential test pressure is to see if there is a difference from what you find for the set pressure.
If for the moment, we neglect the builtup backpressure, then if the pump suction pressure is 10 psig and the relief valve is set at 90 psi then the relief valve will not open until the relief valve inlet pressure is 100 psig. It then becomes important to know the maximum pressure for the pump suction to make sure the valve is set properly to protect equipment and piping downstream of the pump. What's the source for the pump suction? Does the source vessel have a relief valve and what is its set pressure? Unless you have good reason not to use it, you may want to consider the pump suction pressure equal to the source vessel relief pressure plus any static head effects.
With the relief valve setting properly accounting for the superimposed backpressure, you only need to check that the builtup backpressure (psi) is less than or equal to the amount of overpressure (psi) used.
If this doesn't help, come back with more details.