Well, not really.
A NPT is a wedged-in pipe joint designed to carry internal pressure and a nominal amount of bending and static weight by wedging the tapered threads from the "pipe" of some specific known size (1/4 dia through 4 inch diameter for example) and be strong enough to meet moderate internal pressures when sealed by pipe dope, pipe tape, or simple mechanical wedging. But regardless of pressure or the unknown sideways forces, the NPT connection cannot go any deeper (be engaged any deeper into the female threads) than about 1/2 inch. beyond that amount, the two tapered threads (female internal and male external) cannot go further.
So, mechanically, the NPT is stronger as the diamter goes up by the sq of the diameter, but its length is fixed by the thread engagement.
A straight thread cannot carry any internal pressure, but can go as deep into the opening as the designer wants. But it must either seal against a gasket at the bottom, or some mating machined flat or conic surfaces that themselves either seal the joint enough not to leak, or seal between the two joints and a flexible gasket that seals.
You, as designer, decide how deep the straight threads go and the diameter of teh joint. But then again, you (as designer) have to create the seal by some design and part decision.
Be aware that NPT threads are the accepted method for pressure threaded joints, and that straight threads for random commercially-sold parts will need to be tapped by the manufacturer. Water-tight hose-type threads - if your pressure is that low - are commercially/industrially "standard" and could be used. But you need to accept that kind of gasket and low pressure.
Hence my question: What do you need to seal against and what kind of sideways mechanical pressures do you need to resist?