I'll start with an apology; although I work in the UK (where "British" units originated!), my calculations are generally done in metric units, as are the standards I work to (250 Pa is about 1" water gauge, 1 m3/sec is about 2100 cfm). However, here are some typical figures I use when designing for deliberate positive or negative pressures in hospitals, etc:
Leakage through (closed!) doors (m3/second) at stated pressure difference (Pa) across door (m3/second@Pa):
Single Door:
0.03@5, 0.05@10, 0.06@15, 0.06@20, 0.07@25, 0.07@30, 0.08@40
Double Door:
0.04@5, 0.08@10, 0.10@15, 0.11@25, 0.11@20, 0.12@30, 0.13@40
So, for instance, if the room is reasonably well sealed and the bulk of the air leakage is through the standard gaps (4mm along bottom, 3mm along top and sides, 2mm between double leaves) at doors, then:
If it is a single door and the room pressure is 15 Pa above that on the other side of the (only) single door, the leakage out of the room will be 0.06 m3/sec. If the supply air is in excess of the extract air by that amount, then the room pressure will be about 15 Pa above the pressure outside the door.
Beware, it is often the case that other "unexpected" leakage paths, etc occur during construction; these must be catered for as well as the doors.
Regards,
Brian