Entropy is a measure of energy that is available to do work. Such energy has more value than energy that is not available for work. By configuring the process so as to minimize the increase in entropy, you conserve the energy that is available to do work,or you do more work while consuming the same amount of energy. In our market economy, this should also be consistent with minimizing the fuel and electrical consumption of the plant for a given amount of product output from the plant.
Entropy increases when heat is transferred across a large temperature difference, or when a pure substance is mixed with other substances to form a mixture, or when a high pressure gas is throttled across an orifice without doing work.
In a simplistic summary, one should configure the process so that heat is transferred across temperature drops that are minimized ( of course this means much more surface areas is needed), and large pressure drops should be accoplished across turbines or pelton wheels instead of acorss orifices or valves ( and this means a higher capital cost for the rotating machinery).
Breaking down the entire process into individual sub-proceses and calculating each sub process's entropy increase should give the analyst a clue as to where the greates potential for cycle efficiency can be found.