One consideration is the fact that infiltration does nothing to dehumidify the air before it enters the space. This isn't much of a concern in drier climes, but in more humid environments it is of major concern. Positive pressurization of the building through a pre-conditioned central supply system can help in alleviating infiltration caused problems, but in any exterior wind condition over about 5 MPH, the positive aspects of this effect are easily overcome by the velocity pressure of the prevailing wind.
Another thing to take into account is that most building codes (for commercial construction) refer to and require compliance with ASHRAE 62 provisions, which, while offering some calculation alternatives (determining pre-charging and post-charging of the space to achieve adequate air quality on average during occupied periods) to the prescriptive ventilation rates contained therein, are in fact, quite hard to quantify and utilize in most cases, leaving the prescriptive methods to prevail. The quantities of ventilation required to satisfy these prescriptive rates are, by specific requirement of ASHRAE 62, to be supplied continuously during occupied periods. Once again, if some means of positive dehumidification/pre-treatment isn't employed, this can become problematic, at best. Such a condition is of particular problem in DX systems with only simple thermostatic control systems.
Just my 2 cents worth.