IF these are pilot holes, in thin sheet or even moderately thick members, then probably no big deal.
Right-size [1/8-D, this case] "Clecos" have intrinsic ability to shrink small-enough to snake into significantly [0.016-inch or greater] mismatched/off-angle holes... and partially spring-back to hold/clamp alignment "good-enough" for match drilling/reaming surrounding holes up to final diameter where larger clecos can be installed [IE: 1/8, 5/32 or 3/16 D, etc]; then these pilot-hole clecos are removed and their bunged-up holes are drilled to final precision diameter (while the larger surrounding "right size" clecos maintain tightness and alignment).
NOTE. I have seen mechanics use next smaller diameter clecos [ie: 3/32-D this case] to punch-thru and sorta-align/hold/clamp significantly (1/32 or greater) misaligned holes, so that the surrounding holes can be step-drilled into common alignment/size for larger Dia clecos [5/32 or 3/16 1/4 D, etc].
Note.
clecos are a brand-name that identifies the family of temporary hole fasteners.
NOTE.
I real terms, modern tooling should be able to hold within +/-1-deg hole perpendicularity at any surface location. This should occur by a combination of digital definition [3D precision] and/or drill-head sensors that find/touch the surface location and instantly define the precise contour at that exact surface to "set" the best-fit drill-head angle.
Regards, Wil Taylor
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