I use sandvik 880 (U) tipped drills with 2020 grade tips in 321 stainless and other 'difficult' to machine materials (including c22 and c276 hastelloy). They work very well. Through coolant is a must but you can achieve tip life of about 4metres to an edge. Of course this will all depend on diameter and depth of hole. An example of use is a 25mm drill in 321 to a depth of 80mm:- 70m/min spindle speed , .033mm per rev feed, 30bar pressure coolant. We try to keep the swarf like tin foil (as opposed to what is usually told to you by tool reps. ie. heavy feed to introduce chipping) , we found that this was better in keeping the drill from trapping thicker pieces of swarf in the cutting area and causing clogging and tip failure.