Think about what forces will make air pass through an open window-
External wind forces around the building causing differential air pressures so air may be entering on one side, but exiting the open window on the other side of the room.
Stack effect- if the room is high enough and you have some type of ventilator/relief outlet at the high level, the warm bouyant air from the bodies can create some air movement.
Effects of mechanical HVAC systems- if the room has a powered HVAC system - and normally buildings are kept slightly pressurized to reduce infiltration, then how will that induce air in through an open window? Unless you have an exhaust fan in the room that can be controlled to keep the room at a slightly negative air pressure relative to the outdoors.
There are no rules of thumb or quick answers with natural ventilation. There are way too many variables, and the best you can assume is that it "might" be able to provide some supplemental ventilation, if the wind is right, or you use a little brute force powered exhaust. Also- "natural ventilation" is untreated, dust and pollen filled outdoor air at whatever temperature and humidity mother nature provides at that particular time. How will the windows be controlled? What if some idiot leaves them open overnight?
The only way natural ventilation systems can be modelled to get a rudimentary approximation of how opening windows might work is through a whole lotta CFD modelling with a variety of external effects. That's why most building Codes won't allow the use of solely natural ventilation or even a given amount of natural ventilation unless you can prove by modelling/calculations that you can meet the minimum ventilation requirements of ASHRAE-62. You can use CO2 sensors to monitor the system as one way of showing that the natural ventilation system complies, but you still need the proof first before you can allow it to be used effectively.