Just to add a little more the rneills excellent summary. The choice of material can greatly affect the torque required to turn the valve. PTFE and RPTFE have a low coefficient of friction. PEEK, especially virgin PEEK has a relatively high coefficient of friction, so the torque can be excessive.
In addition, you have to look carefully at how the PEEK is manufactured. It can affect the properties tremendously. At about 6 inch and smaller diameter bar, it is typically injection molded. Elongation is around 20%, so the seat will be somewhat flexible. Once you get larger than 6 inch, it is typically compression molded from powder. The elongation drops to 2%. It doesn't flex very much until it breaks.
Just mentioning because you have to be very careful when working with PEEK.