This is a difficult question to answer without more details as to the processes associated with the system. For example, I used to work in a plant where we sent our cooling water and boiler blowdown to our solution mining operations (brine well) for dissolving salt. Since the upwell brine was to be treated anyways, the TDS (and other junk) in the cooling water was irrelevant. My point is that this was an excellent way to reuse cooling water blowdown, but it was entirely dependent on what kind of plant it was.
It would be very difficult to provide a general answer. Things that need to be considered include:
1) What's in your cooling water....this can vary A LOT depending on geography, treatment systems, process, etc.
2) What can your end use tolerate? This can vary even more. Some process waters need to be very pure, in other cases you might only need to filter the water.
3) Only after looking at 1&2 can you begin to assess treatment options...softening, demineraliztion, precipitation, filtration, reverse osmosis, etc, etc, etc.
If you can provide a bit more detail to your query, you will likely be able to get much more informed responses. With enough money, you can turn your cooling water blowdown into the finest drinking water on the planet. However that would probably be a tough sell to management.
If you are looking at one particular plant or complex, I would start by making a list of all the places water is used and the relative quantities (in relation to your typical blowdown volumes). After removing all the items that don't make sense (like the coffee maker in the control room) you can begin to get into details.