Negative. In U.S., duct-mounted smokes are required to serve air handling units with supply air >2,000 cfm, and in each branch of return air systems greater than 15,000 cfm (courtesy of NFPA-90A).
In most of the installations I see, the detector housing uses pitot tube technology in that total (velocity plus static) pressure enters ports in a tube protruding into the air stream, facing the moving air. Static pressure is sensed by a simple tube from the detector housing into the duct. Basically, the difference between the total pressure and static pressure (equal to velocity pressure - preferably 400 feet per minute or greater) drives flow through the smoke detector, which is mounted within a chamber that experiences flow-through by this differential sensed by the tubing protruding into the duct.
Condensation will only occur if the surface temperature within the tubing is below the dewpoint of the air in the duct. Since this is a continually flowing system, the smoke detector sensing tubing attains equilibrium temperature with the duct air temperature. This means that if air doesn't condense randomly within the duct, it will also not condense on the wall of the smoke detector sensor tubing.
Basically, no worries, as long as the sensing location is away from water sources such as humidifiers.
Personally, in my experience, I have never seen problems with condensate adversely affecting in-duct smokes.