First off, what type of semi trailer? Platform, box, tank, end dump, belly dump? Should I go on?
All those have different types of frames and most every type mentioned above has a frameless design.
I have not seen anything published although I have worked with several different trailer manufacturers and I know that they have their own in house propriatary designs. THe frameless tankers while slightly thicker in the tank wall than the frame types are still said by their designers to be lighter than the frame designs.
Some boxes use very little frame and use the box itself as part of the load carrying structure. YOu can watch those going down the highway and watch the stress wrinkles in the side walls every time the thing hits a bump.
Frameless end dumps are lighter, but much more suseptable to tipping over on uneven ground.
All designs have trade offs.
THe DOT regulates how you load the trailers, that is to say how the loads are transmitted to the ground and more importantly to bridges, but they don't care if the trailer is substantial enough to carry the load or not. There are bridge law formulas that give axle spacings and the like for brige law requirements.
My tip is to go to the Society of Automotive Engineers (SAE) website and see if they have any publications that look like what you are looking for.
Are you trying to reinvent the trailer? Why not just go to several trailer vendors and have them bid on your requirements and justify their designs to you?
rmw