Dpc, saford42 will need to use a distribution type software supporting unbalanced LF since I believe PSSE does not support it. A Google search with the following will find some good references for such products: "distribution network analysis"
In North America we use single and multiphase supply for distribution load thus the need to correctly estimate phase voltage and current. Since losses are a function of I2, unbalanced load could result in losses increases but it will be significant for severe load unbalance. Just to illustrate the principle, let's assume that instead of having a perfectly balanced network (1.0 p.u. on each phase), we have 0.9 pu on phase A, 1.0 p.u. on phase B and 1.1 p.u. on phase C we will see losses at 0.81 on phase A, 1.0 p.u on phase B and 1.21 p.u. on phase C giving us 3.02 p.u of losses instead of 3.0 p.u....it's not much but it is there in theory. I am not considering the current in the ground carrying the unbalanced current.
Naturally, there are some assumptions that we have to validate if we want to find out how a voltage unbalance translate into a current unbalance. Is the load constant impedance, constant power, mixed?
Hope this will help
Daniel