High rise buildings sometimes change the advantages of "pushing" through the chiller. In those cases, the return head is of sufficient pressure that NPSH is not a concern, but pressure drop through the chiller, when you already have a huge head to make up, is disadvantageous. If you are dealing with a relatively flat system, and pressure drop through the devices due to friction is the only concern, then you would most often want the pump pumping into the chiller.
The same is true if we are concerned with a boiler, not a hot "water heater" (with a storage tank). That original statement was confusing. If we are talking a hot water boiler, then you have a tube bundle in a heat exchanger, and the chiller-pump strategy in the paragraph above is just as valid - because of pressure drop.
I am glad that others recognized an air separator has nothing to do with it. If you use one, then you should be concerned about its proper placement in the hydraulic circuit, too - but that is a consequence, not a cause.
The expansion/compression tank should be viewed with the same philosphy - it is an accessory, not a prime component in the circuit.
BTW, ad77, what do you call hot water heaters (with a tank)?