If total system dP were 250 ft, and 125 ft of that were in the well tubing, the first pump only needs to be 125 ft. Pressure in the tubing (at the bottom) would be 125 ft + 250 ft static = 375 ft or 162 psi, which is getting up there. If you tried to push it thru the whole loop with just one pump ahead of the tubing, the pressure at the bottom of the loop would be 250 + 250 static = 500 ft or 220 psi. These are high numbers, but the point is, material limitations may govern.