The full vacuum condition could be the prevailing design condition for vessels with low internal design pressure, with minimal external nozzle loading and small wind / seismic loading. However, the full vacuum design for these vessels should not make a such big impact on the shell design, unless the vacuum rings have not been considered.
As for the higher internal pressure vessels (such as 4.5 MPa), the full vacuum design condition is probably covered by the more onerous internal design pressure, hence it wouldn't make any difference to the shell thickness (obviously, subject also of vessel ID).
gr2vessels