It is not uncommon to have a spec break in a line. This is especially common at a block valve. The case may exist, that when the valve is closed, there is a potential for higher pressure on one side of the valve than the other. As a result, it maybe appropriate to have 600 # flanges on one side and 300# flanges on the other side. Of course, in this case, the valve would normally be 600# to satisfy the conditions on the higher side. All flanges should be designed to handle the conditions that they could be expected to see.