Do you mean a Parametric Optimization option? if yes please have look at:
http://www.scribd.com/doc/33254643/Autodesk-Inventor-Assembly-Optimization-Using-FEA-Finite-Element-Analysis
Wojtek
From your description could be something wrong with RAM or the sample block maybe it's too big for a quick refreshing by ACAD.
two ways:
1. check how big is the block if it's above 10MB try "purge" command.
2. download software for optimization RAM like for an example RAMrush
or attach your...
Did you select all points before bolt connection selection or just you selected one point and then after when you selected bolt connection, did you allow to Inventor select itself rest of holes?
I think is better select all working points and then create a bolt connection or create one bolt...