Engine design thrills me - not bugged at all, so give it all you got.
I didn't think the thread was about servicing. So, "gettin the mains right" would not be something inherent. A 90 deg V engine can have lower friction than an inline, inherently. So, more output.
Having to deal with an INHERENTLY longer crank on a inline, maybe using larger journals and a large damper, is an additional deficit. This is more in the realm of original design, I think, not mods or service. But both are worthy subjects.
Flat engines also have high dynamic loads on the mains. The center main on a flat four really gets it bad. No frictional advantage there.
The practical aspects of whether a Ford 300 or 302 , pros and cons is very interesting to me all by itself, though.