Yes, obviously, though the degree and importance of the structural integrity degradation will depend on the core size and location and the specific loading and structural arrangement. Not all rebars will be 100% stressed along their full length so some potential core locations will have a trivial adverse effect.
It is questions like this that should be asked to you local structural engineer and not some internet forum.
Structural engineering is not a free service. These forums aren't either.
**If you have a good relationship with a local structural engineer then you could get your answer for free. But given you are posting here that relationship doesn't exist.