The biggest hole you can make in a B16.5 blind flange without running into additional calculations is found in B16.5 table 6.
What you’re after is called a slip-on flange, which has a Hub at the back end to provide for added reinforcement (compared to the same hole in a similar sized blind flange).
If you need more background, do a search on this site for the same topic, there are numerous past threads with sufficient background details.
Huub