Hi LittleInch, thanks for the comments. I appreciate what you say about simulation, as George Box once said 'all models are wrong, but some are useful'. I think you would be surprised at how the world of engineering is being forced to change by advances in computer science. Slide-rule, followed by Hewlett-Packard, engineering had its place in the 1980s when I graduated, however, today we routinely run FEA and CFD. IoT and IT/OT is about to force engineers to rethink how we do simulation and why.
In my case, there are some specific operating scenarios that warrant what I'm describing. However, I've struggled to find a software package that deals with the specific problem. Instead, engineers are bolting together results from simple boundary case analysis, and phenomenological models in order to design hugely expensive systems. We then cut and paste the design hundreds of times and make Operations sort out the quirks and live with the inefficiencies. As regards batch fluid processing through the same manifold, in this case there is no economical alternative. I suspect there are many more cases if we go looking.