To clarify Paul's finally comment, unreal things (reference geometry to use 3D CAD junkies) can be used as datums as long as they are directly associated with real feaures. See paragraphs under 4.4 of the ASME. There's some good figures in there on how to develop datums.
Ok, just my opinion:
On the drawing you uploaded, Datums B and C are invalid as I interpret the drawing's design intent, though it could be they are associated with the holes along their planes (but I am sure that is not the design intent), in which case they are valid but awkward. The method used to develop B and C looks vaguely based on figure 4.9 of the standard. It's almost as those the designer added small holes along Datum B in order to make it valid, which of course in violation of the design intent (meaning that the datums are not based on anything important and are therefore abritary having no purpose within the design, making them pointless).
Given that assumed error, the control frame in the lower right is also nearly pointless.
Unless there's a whole lot of control framing going on in Detail A (which we can't see) most of the basic dimensions shouldn't be basic because no relationships exist to the locations of the holes and other dimensions or control frames. Just because a dimension happens start in line with a datum doesn't mean the datum is being used to identify its location. You will need a control frame or some further dimensioning to quality the dim as basic. In either case, it seems there is either too many basic dimensions or not enough, depending on what's in Detail A.
(Peeve pet, but not a requirement to fix the drawing: Thread callouts shouldn't normally show drill size unless there some criticallity involved (extremely rare from what I've seen). Listing drill size is redundant to the thread callout and may even be considered a process instruction.)
To do what I think is trying to be done here, new Datums B and C needs to be established based on meaningful features of size and the function of those datums. Many many many more positional tolerances are needed...many more (are they in Detail A?), and a completely new dimensioning scheme is necessary.
To answer your immediate question: the control frame in the lower right it is uninspectable.
Matt Lorono
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