Its all about wind loading. A fully clad portal frame will be subject to loading, both pressure and suction, on the walls which will lead to lateral forces in the plane of the frame and the longitudinal forces will need to be resisted by bracing in the roof and walls.
Frames without cladding, assuming a roof of course, these forces will not be present because the wind will pass through. However, this situation can give rise quite large uplift forces on what is now effectively just a canopy and the frame will need more rigorous checking for stress reversal on the rafters and purlins together with uplift on the bases.