Where 25%C blade C of G would be important:
In a rotorblade, you have 3 factors to consider in torsion....aerodynamic forces, blade weight forces, and the structural resistance to these forces.
Centre of Twist (or sometimes called Centre of Flexure) is the point in a structure at which a coincident force results in zero twist. For a solid extrusion, like one used by pioneering rotorcraft homebuilders, the Centre of Twist occurs near the C of G of the blade.
Many Naca airfoils have optimal performance with the C of P near 25% of chord. By CONVENTION, aerodynamic centre is placed at 25% of chord. Aerodynamic centre merely transforms the CofP value into a moment at 25% Chord. It is an artificial point.
Now, if you are using a solid extrusion and a conventional airfoil that has low moment coefficients and a low variance in moment coefficients (defined at 25% chord by convention)you probably can get away with the assumption that weight balancing at 25% chord will give you good resistance to aeroelastic effects (flutter, etc).
Where this dogmatic approach can get you in trouble or limit your design capability:
Most rotorblades today are of a composite design. They have several materials and thin shell membranes. You have to ask a simple question: Will the steel spar contribute to the torsional rigidity as much as the E-Glass skin. How much weight/torsional rigidity does that planned epoxy leading edge filler provide? To simply balance at 25% chord like a rotorcraft pioneer in the 1950s is dangerous.
You need to account for the weight and aerodynamic moments about the centre of twist. Keeping these factors to a minimum is your priority.
But, stepping away from the dogmatic 25% chord approach to doing proper aeroelastic analysis also frees up your design. You don't necessarily need a blade where the moments are low at the Aerodynamic Centre. You can pick an airfoil with a low variance of moments and create your structure at the points where the moments are minimal.
The short answer to your question is that the 25% chord rule is a classic simplification for solid rotorblades. To use this method for composite blades is potentially hazardous. Proper Aeroelastic analysis is required.
Now, I'll just stand back and await the firestorm from those with a religous fervour of the 25% chord rule

. Debate is good.