First to discuss with the architect on what type of manufacture he had in mind, light assembly, heavy warehouse...etc. The former usually do not possess big problem, design use a reasonably determined uniform load shall suffice; the latter will likely to see equipment load, storage racks, and moving load, that will produces concentrate load on the floor. For manufacturing environment, I prefer to use at least 8" thick slab (10"-12" for known operations are not rare) with two layers of reinforcement. Quite conservative, but provides some flexibility in attracting potential tenants. For your building size, I doubt the latter case will occur. Concentrate on selecting the design load, and provide good joint design. For foot traffic only, 6" slab might just work.