solubility parameters 1

[tp51]

how can I calculate Hansen solubility parameters of liquid pharmaceutical excipients for oral drug delivery?
is it possible to determine saturation amount of liquid excipient in typical solvent as ethanol or acetone?
thanks

 

[pmharper]

Dear Tp51

There are various options for doing this.

1. Use group contribution approach available online (eg:

http://www.capsolva.dk/propertypredict.asp)

2. More advanced "plotting" approches based on whatever solubility data you have available.

For calculating direct solubility one can use Scatchard/Hildebrand theory -- but it will be a rough estimate. Personally I have had more luck in applying local thermodynamic models - however these require some form of experimental data.

Let me know if this is still something you are working on -- I'll be happy to try to guide you in the right direction.

Best regards

Peter