As related to V type, canted cylinder engines, two turbochargers usually offer a distinct advantage over one.
From above, it was briefly touched upon that two turbochargers are usually smaller per unit, but indeed larger when summated and compared to a single. This will, in many cases, permit close proximity installation with regard to the exhaust runner or port. On V engines, you will usually find the turbocharger manifolds or tubular headers feeding directly into the turbine housing. This distance is usually 24 inches or less of linear manifold port length. Comparatively, single unit installations are usually predisposed to having much longer expanses of tubing before reaching the housing inlet.
For example, the single installation requires that both manifolds merge together into one pipe. In the compactness of modern engine compartments, this is usually done behind or under the engine. In rare instances, the manifolds or headers are aimed forward and have a short distance (maybe another 24 inches) to traverse where they meet symmetrically at the housing flange. When this is not possible, a large pipe is used in accordance with maximum flow requirements.
Just as diameter of a tube has a seemingly skewed relationship with maximum flow capabilities (when looked at by the uninformed) so does minimum flow. By using that large pipe, you lose a lot of velocity whilst not at peak flow. With two tubes sized for maximum flow/2 and half the exhaust flow, the difference between minimum flow and maximum is not as great. This can be modeled by using the cross section of the two tubes and a common length.
As was also mentioned, the broad flow and performance required of gasoline engines (compare RPM to that of a diesel) requires the same in a compressor map. Because of the limited low-flow capabilities of these compressors, using two effectively moves the flow requirement higher in the compressor map. As you can see, the compressor map is usually much more efficient at higher pressures and flow rates than low pressures and flow rates. If you size the twins too large, you forfeit this advantage. Think of it this way, if you ran 4 respectively smaller turbos, they would provide better efficiency down low and roughly equal efficiency mid and high in the map versus two, and two would do the same versus one. So, four is that much better than one. With simple regard to the compressors, this progression goes on and on. When you start factoring in real world constraints and duty efficiency, you see why people use one, and not four.
Hope this helps a bit.