Back to original question:
1. Valve closed will remain closed.
Reason as given by others above: friction, torque, actuators holding force and locking. In addition: geometry will not give anything but increased pressure against the whole seat by increased pressure on the disc, in preferred flow direction.
True: for most valves of this type, the construction will normally set a limitation of the overpressure in the 'not prefered' flow direction. The construction is however always such to include (and specificfy) the maximum allpowed pressure this way. Normally this pressure will be at least up to and including the pressure classes working test pressure with closed valve (both ways), but practical pressure might be allowed higher (by the manufacturer) the prefered way.
2. By opening valve, forces will be balanced and caretaken by construction.
Any valve, offset or not, will be exposed to different forces by the fluid flow and pressure when opened. Any good constructed valve is arranged and tested with maximum conditions given. Quality valves can be recognized by solid stems, stem bearings, sealing constructions, solidity and methode of stem fastening to disc, disc construction and actuation construction.