A much simpler approach to the same end result (or better) is a high compression engine that runs on regular fuel, and doses anti-detonation fluid as needed in the upper load range (which is rarely used by most drivers under most conditions).
This was the practice on highly rated reciprocating aero-engines in the 40s and 50s, albeit using already high octane gasoline. But then again, they took advantage of all the octane also at cruise power, which is a much higher fraction of full load than typical automobile engines.
While these aero-engines aren't high compression by typical modern automotive standards, keep in mind they are highly supercharged at take-off power.
In a modern automotive application, there would be a fail-safe derate in the event of lack of fluid. Improper fluid would be detected via excessive knock, with attendant mitigation steps and trouble codes.
"Schiefgehen wird, was schiefgehen kann" - das Murphygesetz