Well, nozzle loads are usually unknown, which is why nozzle load tables are used as an interface document between the vessel fab and piping guy - with this doc the vessel fab knows the minimum and the piping guy the maxmimum.
It's not a 100 perfect solution (are the loads e.g. primary or secondary loads, do they act together, what other combinations are possible, etc.) but it works out very well in most cases. With this document the vessel fab therefore has a theoretical upper limit (i.e. nozzle loads) to which he could check the supports. However, chances are the nozzle loads will never act in the most worst case situation but more likely in a situation where one cancels the other, or where the resultant vector is negligible wrt to the supports.
This is my experience, but my scope of vessels is usually rather limited in size (small volumes of a few millilitres to maybe a few cubic metres). Not sure what would happen with a 60 mtr column where the top nozzle loads gives a side load. Think of that (for a) moment ...