When I look at multiple features acting as a single datum I think of the fixture that would simulate that datum. If it's a pattern of holes, the fixture will have a pattern of pins. It isn't necessary to have any particular location or orientation derived from the holes; as long as the reference to the datums can be seen as related to the datum simulator, that is good enough. The confusion is that the datums don't move, the part does; it only looks like datums follow the parts around.
For a clear example of deriving, look at the figure where there is a sloped feature that is met with a sloped datum simulator, but the datum itself is not sloped.
The problem that comes from multiple features are from two sides.
First, if the features are referred to as RFS, it used to be indistinct if they are to be simulated with exactly simultaneously expanding pins that stop expanding once location and orientation are set or if some other condition should happen. I dislike the use of this case because I haven't seen a real application where multiple simultaneous expanding features would mate with a part.
Second, if they are MMC or MMB or whatever the new terms are, then the location and orientation of the part relative to the datum simulator are not unique, which presents a problem with CMM software looking for a single answer from which to derive an exact reference frame. This case is similar to the case when only a single hole is used, but CMM software can be written to handle the special cases of a single hole or a single slot; randomly located and shaped features requires a more sophisticated approach.