Seeing where this thread has gone I would like to voice one more, perhaps somewhat cautionary, observation/opinion. While not intending to counter any advice previously given, nor to start a grand debate on the issue, you may wish to check with the designer/manufacturer(s) of the specific flanged items involved, including sealing gasket, to see whether they feel flanged joint "lubrication" is a good idea. Of course it would appear the pressure peformance of simple flat-face flanges without o-ring grooves and e.g. simple flat or other rubber flanged gaskets used with same e.g. must be dependent on the rubber staying between same. It would appear in these particular cases this is basically by virtue of the friction developed between the surfaces in the bolting assembly process. It would also appear this friction, and therefore perhaps also at least very high pressure retention, of at least those sorts of gaskets/joints, might in theory be reduced due by the use of effective "lubrication". In other words, perhaps some unlike many other pipe joints where lubrication is undeniably invaluable for optimum perormance, lubrication could theoretically hasten "blow-out" of gaskets in some flanged joints (perhaps particularly with undependable bolting forces and/or very high pressures).