Higher Grade Bolts vs. Lower Grade Bolts Benefits

[struclearner]

One of the advantage of using higher grade bolt is to get higher clamping force and higher compression between the joint members giving a higher factor of safety against joint separation.
Does the higher grade bolts with higher torques also helps in vibration loading only, in the absence of other loads (tensile or shear) on the joint as compared to using low grade bolts.
What other potential benefits of using higher grade bolts are, and not using the lower grade bolts.

Thank you very much for your response and valuable comments.

 

[BrianE22]

I questioned the same thing - (4) 3/8" diameter bolts for a 60,000 Lb load?

 

[Tmoose]

Based on uniform load sharing and various Internet tables and the HoloKrome manual for clamp load I get:
Qty
18.8 (19) Grade 2 UNC screws
16.7 ( 17)Grade 2 UNF screws
6.4 (7)UNC SHCS
5.6 (6)UNF SHCS.

Edit - added this - Assumptions aplenty, and significant figures completely ignored in the above KalKalAtion.