Looks like you're trying out PostBuilder...
Yes, you can change just about anything.
By changing that to Head, you realize it goes from a Head/Table to a Head/Head setup - completely different machine configurations. You have to be aware of the underlying values assigned to that axis such as the pivot offset and rotation limits as the major issues.
Yes you can change axis headings. I think the first thing you should do is make sure that your MCS of your model in CAM matches the MCS of your machine.