Thanks. It is a lot more clear what you have to do now.
I would think that your start up problem is coming from having to "hydraulically" add the slope between 6 Km and 5 Km to the slope at 4.25 Km to 3.25 Km. When you get high discharge pressure during start-up, the flow up to the first peak is low, so when it reaches the peak without enough of a flowrate to fill the downhill segment quickly, the water simply cascades (flows half-full over the peak to a partially filled down-sloped pipe) filling the bottom of the valley. You get no benefit in driving the water up the next hill from that partially filled segment. When pressures at the top of the first peak are low, the volume of air is high. As pressures increase, the volume of air will markedly decrease. Your pumping effort goes into compressing the air in that downhill slope, until it is finally enough to start filling it full of water and begin driving the water and the now lower volume air up the next hill. The same phenomenon may also happen, probably to a lesser extent, across the other local peaks. You won't stop the cascading with an air releas valve at the top of the first peak. Any air will be forced out, but only to be replaced with water vapor in the downslope until the pressure is able to be increased in that segment.
Due to NPSH concerns, I don't think it makes much sense to move the pumps any farther than Km 5.3
Other than that, the profile is not as bad as I thought and I agree that once the air is forced out of the pockets, the constantly increasing average slope should be easier to work with.
The discharge head required at the pump looks to be 125 m or so + whatever flow losses you have from the beginning to the end, so it will be pretty high all the time and may approach as high as 325 m on pump shutdown and during other times of very low flow especially if there is some chance for some quick reverse transient flows during pump shutdown, which I would guess that there is. Take care.
From "BigInch's Extremely simple theory of everything."