renasis,
Deriving a datum from one of your hole patterns (for using it as a reference for the other one, in your case) is usually done with the hole pattern referenced in MMB, from practical reasons (the ability to use a fixture with fixed size pins as datum simulators rather than simultaneously expanding ones). This results in datum shift (possible displacement of the controlled pattern as a group, made possible by the relative mobility between the part and the simulated datum), and that datum shift may reduce the accuracy of the alignment you want to achieve anyway. Referencing the hole pattern at RMB can allow controlling the alignment most accurately, but it also may result in technical difficulties and possibly additional cost. With the method I suggested (which is based on a Simultaneous Requirement as described in ASME Y14.5) you should be able to control the relative alignment tightly enough for most cases, by assigning the appropriate position values for both patterns, relative to the same datum reference frame.